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KMID : 0377619900550070445
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Korean Jungang Medical Journal
1990 Volume.55 No. 7 p.445 ~ p.451
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Antimicrobial Effect and Combined Effect of Rifampin and Quinolone to Staphylococcus aureus
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Abstract
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Methicillin susceptibility test for 29 strains of Staphylococcus aureus isolated from clinical specimens was done by oxacillin disc diffusion method.
In the test, methicillin-resistant-Staphylococc. is aureus (MRSA) and Methicillin-susceptible-Staphylococcus aureus (MSSA) were 19 (65 %) and 9 (31 %) strains, respectively.
MICs (minimal inhibitory concentration) to rifampin, nalidixic acid, pipemidic acid, ciprofloxacin, enoxacin, ofloxacin, and norfloxacin were tested against MRSA and MSSA. (Table 1, 2).
As results of antibiotic combination tests of Rp + Na, RP + Pa, Rp + Cx, and Na + Pa, Rp + Cx and Rp + Pa exhibited relatively high antagonism. But, in the. case of RP + Na, all strains of MSSA did not show any antagonism against this combination. Combination of Na + Pa exhibited one antagonistic strain of MRSA and MSSA each.
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KEYWORD
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